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Acantholysis etymology

Acantholysis Medical Definition Merriam-Webster Medical

: loss of coherence between keratinocytes of the epidermis that is due to breakdown of desmosomal intercellular attachments and is characteristic of various conditions (as pemphigus and herpesvirus infection) marked by vesicular eruption Other Words from acantholysis Etymology acanth +‎ -osis (diseased condition Definition of acantholysis in the Definitions.net dictionary. Meaning of acantholysis. What does acantholysis mean? Information and translations of acantholysis in the most comprehensive dictionary definitions resource on the web 1. Vestn Dermatol Venerol. 1975 May;(5):17-22. [Origin and nature of acantholytic cells in pemphigus vulgaris]. [Article in Russian] Rodin IuA, Shapovalov IuN, Pototskiĭ II, Dolgov AD diffuse hypertrophy or thickening of the prickle cell layer of the skin. adj., adj acanthot´ic

acanthosis - Wiktionar

What does acantholysis mean? - definition

Acantholytic squamous cell carcinoma is a rare variant of squamous cell carcinoma in the mucosa of upper aerodigestive tract. Histomorphologically, acantholytic squamous cell carcinoma may lose the typical features of conventional squamous cell carcinoma and mimic other epithelial or mesenchymal malignancies due to advanced acantholysis and dyskeratosis Acanthosis nigricans is a skin condition characterized by areas of dark, velvety discoloration in body folds and creases. The affected skin can become thickened. Most often, acanthosis nigricans affects your armpits, groin and neck. The skin changes of acanthosis nigricans (ak-an-THOE-sis NIE-grih-kuns) typically occur in people who are obese. Failure of desmosomal adhesion with ensuing keratinocyte separation - a phenomenon called acantholysis - can result from genetic, autoimmune or infectious proteolytic causes. Rare hereditary disorders of desmosomal formation have been identified in animals Epidermolysis bullosa (EB) is a group of inherited diseases that are characterised by blistering lesions on the skin and mucous membranes. These may occur anywhere on the body but most commonly appear at sites of friction and minor trauma such as the feet and hands

skin disease autoimmune disorder disease of the skin skin disorder acantholysis autoimmune disease Etymology pemphigus (English) πέμφιξ (Ancient Greek (to 1453)) Featured Games Trending Searches henbane creative gujarati. A punch biopsy obtained from his palm demonstrated epidermal papillomatosis and orthohyperkeratosis, as well as partial acantholysis in the granular and spinous cell layers, compatible with striate PPK (Fig. 2). 2 Direct sequencing of DSG1 demonstrated in exon 5, a single nucleotide change c.395C>A converting a serine residue (TCA) to stop. n atrophy A wasting of the body, or of a part of it, owing to defective nutrition. n atrophy In botany and zoology, arrested development of an organ due to stoppage of growth at any stage by the operation of causes either external to or inherent in the organism. atrophy To waste away

[Origin and nature of acantholytic cells in pemphigus

phialed vs phiale. phials vs phiale. terms vs pial. pal vs pial. pial vs phal. pial vs pibal. vial vs pial. phan vs phal. peal vs phal Disorders of keratinisation. Created 2009. Learning objectives. Describe common features of lichen planus, lichen sclerosus, ichthyosis, pityriasis rubra pilaris, Darier disease and keratosis pilaris Lichenoid diseases. Many skin diseases include the term 'lichen', which is thought to originate from a resemblance to the lichen that is found on trees Definition of Acantholysis. 1. Noun. (medicine) The loss of intercellular connections, resulting in loss of cohesion between keratinocytes, seen in diseases such as pemphigus vulgaris. ¹. ¹ Source: wiktionary.com. Medical Definition of Acantholysis. 1 Acantholysis is a 12 letter word, used as a noun, and has the letters aachilnossty (achilnosty). Starts with a, ends with s, eight consonants, four vowels and five syllables. Learn how to use the easiest words finder here. Word lists are in the order of the most common words and most searched. 12 Letters Acantholysis is the loss of cohesion between keratinocytes as a result of dissolution of intercellular connections, sometimes resulting in an intraepidermal vesicle. What is Acanthotic squamous epithelium? Acanthosis: thickening of epidermis (squamous layer); rete ridges usually extend deeper into dermis

Acanthosis definition of acanthosis by Medical dictionar

Acantholysis. Acantholysis is the loss of cohesion between epidermal (or epithelial) cells leading to the formation of intraepidermal clefts, vesicles, or bul-lae. Primary acantholysis results from dissolution or separation of the desmosomes between unaltered cells. Secondary acantholysis occurs between damaged cells such as during viral. acantholysis in cultured human skin (1) and the destruction of epidermal cells (2). Successively, several authors have provided this evidence in studies in vivo. In a recent study, Amagai et al. have generated a novel experimental murine PV model by transferring splenocytes from a Dsg3-Key words: pemphigus, citokyne, acantholysis, skin, immune. acantholysis is correlated with its distant metastasizing behavior [10]. Ishikawa et al. in their study found that 46-month survival for ASCC was zero percent whereas 30-month survival was just 20.4% and concluded the ASCC of the oral cavity to have an extremely poor prognosis. The study has also analyzed the treatment protocol opted i As nouns the difference between cantholysis and acantholysis is that cantholysis is the surgical division of the canthus while acantholysis is (medicine) the loss of intercellular connections, resulting in loss of cohesion between keratinocytes, seen in diseases such as pemphigus vulgaris

The acantholysis was observed after only a 12-h incubation and was most marked after a 24-h or 48-h incubation. Following this, the histological change was gradually replaced by the degenerative change of keratinocytes. On the other hand, once the degenerative change was marked, no acantholysis was observed for up to 4 days of culture (Figures. acantholysis factor was obtained, the fetal calf serum was omitted from the medium. For these experiments, approximately 50 explants (3 mm x 3 mm x 0.3 mm thick) were placed on lens paper rafts and floated on 3 ml medium containing control or pemphigus IgG. After 5 days the explants were immersed, briefly equilibrated in the medium. Acantholytic: squamous cell carcinoma with acantholysis, pseudoglandular ( CEA negative) Acantholysis is the loss of cell to cell connections between keratinocytes, resulting in loss of intercellular cohesion. Invasive Bowen disease: invasive islands of squamous and basaloid cells with overlying classic Bowen disease

Etymology and pronunciation. The word hyperkeratosis (/ ˌ h aɪ p ər ˌ k ɛr ə ˈ t oʊ s ɪ s /) is based on the Ancient Greek morphemes hyper-+ kerato-+ -osis, meaning 'the condition of too much keratin' Pemphigus is a group of life-threatening blistering disorders characterized by acantholysis that results in blisters in mucous membranes and skin 1). Blisters tend to form when the skin is rubbed (Nikolsky sign). Acantholysis is when skin cells are no longer being held together. Pemphigus patients develop mucosal erosions and/or blisters. Acantholysis. Acantholysis is the loss of cohesion between epidermal (or epithelial) cells leading to the formation of intraepidermal clefts, vesicles, or bul-lae. Primary acantholysis results from dissolution or separation of the desmosomes between unaltered cells. Secondary acantholysis occurs between damaged cells such as during viral infection Familial acantholysis of Angus calves and hereditary suprabasal acantholytic mechanobullous dermatosis of buffaloes appear to be similar to acantholytic epidermolysis bullosa of human beings. A genetic acantholytic dermatosis resembling human Darier disease has been rarely recognized in dogs. In autoimmune blistering dermatoses, circulating.

Bullous pemphigoid is the result of an attack on the basement membrane of the epidermis by IgG +/- IgE immunoglobulins ( antibodies) and activated T lymphocytes (white blood cells). The target is the protein BP180 (also called Type XVII collagen ), or less frequently BP230 (a plakin). These proteins are within the NC16A domain of collagen XVII The remaining 8 patients, in whom acantholysis was not present, had undergone reversal of the cutaneous lesions during a period ranging from ten months to three years; 1 of them had died of carcinoma of the intestine and 1 had died of cardiac disease. Pemphigus Foliaeeus.—Twelve of the 14 biopsies made in this group showed acantholysis (fig. 4) ACANTHOLYSIS is defined as the loss of coherence between epidermal cells due to the breakdown of intercellular bridges, called desmosomes. The cells remain intact but are no longer attached to each other. Cells tend to acquire the smallest possible surface area and become rounded, resulting in intra-epidermal clefts, vesicles and bullae phaal vs phall - what is the differenc

BACKGROUND: Grover's disease (GD), or transient acantholytic dermatosis, is a pruritic, papulovesicular eruption characterized histopathologically by acantholysis with or without dyskeratosis. The origin of GD is unknown. Suggested causes include sweating, heat, immobilization occlusion, external beam and ultraviolet radiation, and xerosis CL-387,785 - CAS 194423-06-8 - Calbiochem A cell-permeable and irreversible inhibitor of EGF-receptor (EGFR) kinase activity in vivo (IC₅₀ = 250-490 pM) as well as EGF-stimulated autophosphorylation of tyrosine residues in the EGFR in vivo (IC₅₀ = 5 nM).; CAS Number: 194423-06-8; Synonyms: CL-387,785 - CAS 194423-06-8 - Calbiochem,N-4-(3-Bromophenyl)amino-6-quinazolinyl-2-butynamide. Can is a synonym of tin. Tin is a synonym of can. As nouns the difference between tin and can is that tin is (uncountable) a malleable, ductile, metallic element, resistant to corrosion, with atomic number 50 and symbol sn while can is a more or less cylindrical vessel for liquids, usually of steel or aluminium. As verbs the difference between tin and can is that tin is to place into a tin in. The involvement of ADAM10 in acantholysis in mucocutaneous pemphigus vulgaris depends on the autoantibody profile of each patient. M Ivars et al. The British journal of dermatology, 182(5), 1194-1204 (2019-08-02) Acantholysis in pemphigus vulgaris (PV) may be triggered by desmoglein (Dsg) and non-Dsg autoantibodies. The autoantibody profile of.

Pemphigus: Etiology, pathogenesis, and inducing or

  1. epidermal acantholysis, hyperkeratosis, parakeratosis, inflammation, margin status, frozen section results, lymph node status, immunoprofile, and histochemical stain results. Results: Of the 56 patients identified, the mean age at diagnosis was 69 years, and most patients were Caucasian. The presenting symptom was itching, often with burning
  2. Bullous pemphigoid is an uncommon blistering disease of the elderly, which often starts with itch and urticated and erythematous lesions. Later, large tense blisters develop on both erythematous and on normal skin and there may be mucosal involvement with blisters and erosions. The blisters are subepidermal. Bullous pemphigoid is the most commonly seen autoimmune blistering disease in the West.
  3. Keywords: Acantholysis, Atypical, Grover's disease, Transient acantholytic dermatosis. Case report. A 55-year-old male presented to the dermatology clinic for the evaluation of progression of intensely pruritic erythematous papules and plaques on his trunk, upper extremities, neck, and face over eight months
  4. Pemphigus vulgaris is an autoimmune disorder.In the case of pemphigus vulgaris, the immune system mistakenly produces antibodies against specific proteins in the skin and mucous membranes, known as desmogleins. These proteins form the glue that keeps skin cells attached and the skin intact. When desmogleins are attacked, skin cells separate from each other and fluid can collect between the.
  5. Start studying 40 (questions) 3. Learn vocabulary, terms, and more with flashcards, games, and other study tools

Acantholytic, Vesicular, and Pustular Disorders Plastic

Actinic keratosis is an erythematous scaly papule or plaque that develops on sun-damaged skin as a result of chronic exposure to ultraviolet radiation, typically in elderly patients with lighter skin types. This condition is related to squamous cell carcinoma of the skin and is often described as a precursor or early form of squamous cell carcinoma in situ, although most actinic keratoses will. Grovers - Finger like epidermal proliferation with corp ronds and grains and focal acantholysis. EM and Fixed drug can look very similar ropey collagen above post capillary venule. No desmoglien 1 in mucosa. Subcorneal vesicle with neutrophils - Candida, impetigo, psoriasis, Sneddon Wilkinson, Scabies. Indirect Immuno in EBA and BP

Histology shows suprabasilar acantholysis (i.e. loss of cell-cell adhesion in the basal and immediate suprabasal area). This is most prominent on oral and vaginal mucous membranes, but is also seen on the skin and eyelids. The mice start to lose hair at 3-4 weeks Start studying PATH DERM 1-2-3-4. Learn vocabulary, terms, and more with flashcards, games, and other study tools Apoptosis plays a role in pemphigus IgG-dependent acantholysis; theoretically, the blockade of the caspase pathway could prevent the blistering that is caused by pemphigus autoantibodies. Using this strategy, we attempted to block the pathogenic effect of pemphigus IgG in Balb/c mice by using the caspase inhibitor Ac-DEVD-CMK. This inhibitor was administrated before the injection of pemphigus.

Pemphigus is a group of autoimmune blistering disorders associated with autoantibodies against the keratinocyte cell surface. Pemphigus has three major variants: pemphigus vulgaris (PV), pemphigus foliaceus (PF), and paraneoplastic pemphigus (PNP) which all have further subtypes. The variants of pemphigus are classified depending upon the clinical and histological features, immunofluorescence. The exact mechanism of acantholysis induction from this medication is unknown. Because imiquimod is known to cause a localized immune response at the site of application, the generation of antibodies to desmoglein 1 has been postulated as a mechanism of action We studied neuroendocrine mediator regulation of adhesion and motility of human epidermal keratinocytes (EK) and found that cholinergic compounds control EK cell‐matrix and cell‐cell attachment. In this study, we tested the anti‐acantholytic activity of muscarinic agonists in pemphigus and non‐pemphigus acantholysis, and investigated the effects of pemphigus antibody (Pab) on the the. Epidermolysis bullosa is a rare and painful skin disorder has no cure. Learn more about the symptoms, causes, diagnosis, and treatment of epidermolysis bullosa Warty dyskeratoma (WD) is a benign epidermal proliferation first reported in 1957 because of its distinctive histologic findings. WD presents as an umbilicated papule with a keratotic plug, usually limited to the head, neck, or face

Abstract Darier disease and Hailey-Hailey disease are autosomal dominant genodermatoses caused by mutations in genes encoding Ca 2+ ATPase pumps in the endoplasmic reticulum (SERCA2) and Golgi apparatus (hSPCA1), respectively. As a consequence, abnormal intracellular Ca 2+ signaling leads to impaired processing of junctional proteins, resulting in acantholysis due to disrupted epidermal. Shingles is a rash with shooting pain. It usually shows up on just one side of your body. Learn more about shingles symptoms, causes, contagiousness, vaccine, diagnosis, and treatment Marked acantholysis was visible and upper layers of epidermis were absent. Serum IgG, but not IgG4, autoantibodies of pemphigus type against desmosomal proteins of keratinocytes were present in IIF on rabbit labial mucosa and normal human skin, of titers respectively 1/40 and 1/160. The diagnosis of PF was made Figure 2: A biopsy showing focal acantholytic dyskeratosis, focal suprabasal acantholysis, and intense inflammatory infiltrate, composed mainly of lymphocytes, in the papillary dermis (H&E, 100×). Systemic and topical steroids reduced the lesions and the patient was instructed to avoid such predisposing factors as heat, excessive sweating, and. Pemphigus Vulgaris. Pemphigus is a group of organ specific autoimmune diseases characterized by the production of autoantibodies to desmogleins. They are mucocutaneous blistering diseases that demonstrate a loss of cohesion of the epidermal cells (acantholysis) which result in the formation of clefts in the epidermis

Pemphigus - Wikipedi

True pemphigus (synonym: acantholytic pemphigus) is a severe chronic recurrent, autoimmune disease of the skin and mucous membranes, the morphological basis of which is the process of acantholysis, a violation of the connections between epidermal cells. Bubbles arise from acantholysis. The mechanism of immune disorders is not fully established Trending Searches creative aesthetic negative-impact for-the-first-time brainstorm sexual-arousal alimentary good availability focus mantra online specialize processing coordination intervention kick-start doddle white-person out-of-the-box thinking know-it-all gujarati troubleshoot challenge more-likely experience develop epidemiology center important invasive overzealous love detect.

Pemphigus can occur on its own or manifest as a feature of certain autoimmune diseases or cancers. Pemphigus may also be triggered by certain drugs. The diagnosis typically involves a biopsy of the skin or mucous membrane. Treatment may include oral or injected steroids, immunosuppressant medications, intravenous antibodies, and biologic drugs WikiZero Özgür Ansiklopedi - Wikipedia Okumanın En Kolay Yolu . Hyperkeratosis is thickening of the stratum corneum (the outermost layer of the epidermis, or skin), often associated with the presence of an abnormal quantity of keratin, and also usually accompanied by an increase in the granular layer. As the corneum layer normally varies greatly in thickness in different sites, some. Definition of acantholytic in the Definitions.net dictionary. Meaning of acantholytic. What does acantholytic mean? Information and translations of acantholytic in the most comprehensive dictionary definitions resource on the web Acanthocytosis definition, a condition characterized by large numbers of acanthocytes in the blood. See more

Familial Acantholysis 475 Fig. 2. Hind foot ofan affec ted ca lf. Results Necropsy Findings All calves were in poor to emaciated condition. There was an ulcerative and exudative inflammation of the skin particularly affecting the lips, naso terized histologically by acantholysis, papilloma­ tosis, and intraepidermal microabscesses con­ taining acantholytic keratinocytes, eosinophils, and/or neutrophils.2,12 Pemphigus foliaceus and pemphigus erythematosus appear histologically similar. They are characterized by intragranular or subcorneal cleft and vesicle formation an Microscopic examination of stained sections of a biopsy of one of these lesions would show features of dyskeratosis (abnormal maturation of keratinocytes) and acantholysis (separation of keratinocytes by dissolution of intercellular connections). The clinical spectrum of disease is a reflection of the spectrum of pathological findings

Hyperkeratosis - Wikipedi

Acute febrile neutrophilic dermatosis (Sweet's Syndrome) Condition characterized by large, rapidly extending, erythematous, tender plaques on the upper body usually accompanied by fever and dermal infiltration of neutrophilic leukocytes. It occurs mostly in middle-aged women, is often preceded by an upper respiratory infection, and clinically resembles erythema multiforme The pemphigus complex is a group of uncommon autoimmune dermatoses characterized by acantholysis. Acantholysis is the breakdown of intercellular desmosomal bridges, deep in the epidermis, resulting in the release of individual, rounded keratinocytes that have large, dark-staining nuclei. These cells are known as acantholytic cells (FIGURE 3) plete acantholysis with cleft formation of the lower and middle epidermis. In autoimmune diseases, circulating autoantibodies bind to the extracellular segments of desmosomal proteins, interfere with desmosome adhe-sion, signalling and assembly thereby resulting in acan-tholysis. Autoantibodies against deep epiderma A 62-year-old man presented with a two-month history of asymptomatic, progressive thickening of both nipples and areolae. Lesions initially appeared on the left side, and then spread to the right. Hyperkeratosis is thickening of the stratum corneum the outermost layer of the epidermis or skin often associated with the presence of an abnormal quantity of keratin1 and also usually accompanied by an increase in the granular layer. As the corneum layer normally varies greatly in thickness in different sites some experience is needed to assess minor degrees of hyperkeratosis

Transient Acantholytic Dermatosis - an overview

High-dose pemphigus antibodies against linear epitopes of desmoglein 3 (Dsg3) can induce acantholysis and depletion of Dsg3 from keratinocytes. Download. Related Papers. Controversial role of antibodies against linear epitopes of desmoglein 3 in pemphigus vulgaris, as revealed by semiquantitative living cell immunofluorescence microscopy and in. This new species can be distinguished from other species in this subsection by the lepidote-stellate trichomes on young branches, petioles, inflorescences and hypanthia, leaves with suprabasal nerves and wrinkled/auriculate bases, abaxial leaf surfaces with only sparse trichomes, a 5-locular ovary, and large mature fruits (10-13 × 12-15 mm) with up to 15 seeds, which are 2.5-3.5 mm long acantholysis, (2) direct immunofluorescence (DIF) showing intercellular and basement membrane staining (for IgG and Compliment), and (3) indirect immunofluorescence (IIF) staining with rat bladder epithelium for circulating autoantibodies. Presence of 3 major or 2 major and 2 minor of these criteria is considered diagnostic. Response t

Click on the first link on a line below to go directly to a page where acantholysis is defined. General (11 matching dictionaries) acantholysis: Vocabulary.com [home, info] acantholysis: Wordnik [home, info] acantholysis: Wiktionary [home, info] acantholysis: Dictionary.com [home, info] acantholysis: UltraLingua English Dictionary [home, info Epidermis exhibited marked hyperplasia, parakeratotic hyperkeratosis, and moderate acantholysis. Epidermal cells were swollen, with foci of ballooning degeneration, and the cytoplasm of scattered epithelial cells contained round eosinophilic inclusions of varying size. No intranuclear inclusions were found. We also observed ulcerated epidermis. Essential features. Mycosis fungoides (MF) is a clinical diagnosis that requires strong correlation with histopathologic and sometimes molecular findings to exclude benign inflammatory diseases, more aggressive primary cutaneous lymphomas, and extracutaneous lymphomas that can involve the skin. Conventional MF begins as eczematoid or. It is as a result of acantholysis that severe blisters develop on the skin and/or mucosal membranes. 3 Anti-DSG antibodies are hypothesized to result in acantholysis through two mechanisms: (1) auto-antibody-mediated steric hindrance of desmosomal adhesion and/or interference with desmosome assembly, and (2) intracellular cell signaling. Pemphigus herpetiformis is a rare variant of vulgar pemphigus, clinically resembling dermatitis herpetiformis (vesicles, papules, strong pruritus) and histologically is characterized by acantholysis and positive immunofluorescence finding. Inflammatory infiltrate is of variable density, with admixture of eosinophils and/or neutrophils

acantholysis - Academic Dictionaries and Encyclopedia

  1. High-dose pemphigus antibodies against linear epitopes of desmoglein 3 (Dsg3) can induce acantholysis and depletion of Dsg3 from keratinocytes. By Alessandro Lanza. A novel method to investigate pemphigus-induced keratinocyte dysmorphisms through living cell immunofluorescence microscopy
  2. The earlier peak of p38MAPK activation is part of the mechanism leading to acantholysis, whereas the later peak of p38MAPK and apoptosis may not be essential for acantholysis . Regarding to the possible role of apoptosis, there is an alternative explanation of acantholysis in which the cells shrink and separate without affecting the desmosomal.
  3. Cantharidin is an odorless, colorless compound that is soluble in various organic solvents but only slightly soluble in water. It is highly irritating and causes acantholysis and vesicle formation when in contact with skin or mucous membranes. After ingestion, it is absorbed from the GI tract and rapidly excreted by the kidneys
  4. ORAL MANIFESTATIONS : Intact bullae rare due to fragility Patchy erosions are seen- painful on chewing Desquamative gingivitis (2-3%) Common sites- Buccal mucosa Tongue Palate Lips Supriya.s.Venugopal et al, 2012, [DIAGNOSIS AND CLINICAL FEATURES OF PEMPHIGUS VULGARIS ] 23
  5. 6. Definition of acantholysis, with etymology, pronunciation (phonetic and audio), synonyms, antonyms, derived terms and more about the word acantholysis . chicken pox - fordítás - Angol-Magyar Szótár - Glosb . Quickly Soothe Blisters, Chicken Pox, Bumps, Rashes, Bug Bites
  6. Title:Apoptotic Pathways in the Pathogenesis of Pemphigus: Targets for New Therapies VOLUME: 13 ISSUE: 10 Author(s):Roberta Lotti, Alessandra Marconi and Carlo Pincelli Affiliation:Institute of Dermatology, School of Biosciences and Biotechnologies, University of Modena and Reggio Emilia, Via del Pozzo, 71 41100 Modena Italy. Keywords:Acantholysis, antibodies, apoptosis, caspases, desmoglein.

Acantholysis Meaning Best 1 Definitions of Acantholysi

acantholysis - definition and meanin

Detailed Description. Plakoglobin Jup null-mutant embryos die from embryonic day 10.5 onward due to severe heart defects. Some mutant embryos develop further, especially on a C57BL/6 background. These mice die around birth, presumably due to cardiac dysfunction, and with skin blistering and subcorneal acantholysis Acantholysis and dyskeratosis are the typical histological findings. The underlying defect is a result of mutations in the ATP2A2 gene on chromosome 12q23-24 that encodes for a sarco/endoplasmic reticulum calcium ATPase (SERCA 2). Acantholysis is thought to result . Treatment. • A 13-year-old child is described who presented with generalized pemphigus vulgaris associated with extraordinarily high titers of circulating autoantibodies against the pemphigus antigen. Because of the lack of response to treatment with reasonably high doses of oral corticosteroids, as well as..

Acanthocyte definition of acanthocyte by Medical dictionar

How to pronounce acantholysis HowToPronounce

The acantholysis may also form anastomosing spaces and channels mimicking angiosarcoma. Acantholytic SCC must be differentiated from adenosquamous carcinoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma. Prognosis is similar to that of SCC. However, some reports suggest a more aggressive behavior (Barnes et al., 2005; Thompson, 2006).. A 45 year old man presented with abdominal pain, loss of appetite, and significant weight loss over a period of about four weeks. Imaging of the abdomen showed a mass in the region of the head of the pancreas. In view of the size of the mass and the clinical picture, a Whipple's procedure was performed. Histological evaluation of the pancreatic tumour showed an adenosquamous carcinoma. Darier disease (DD), also known as dyskeratosis follicularis, is a rare genodermatosis classically characterized by persistent hyperkeratotic papules and plaques affecting the seborrheic areas. Due to its variable expressivity, it can present with very discrete clinical features for many years, leading to diagnostic errors and incorrect treatments Thiol drugs provoke acantholysis in vitro possibly by increasing the activity of plasminogen activators. An active amide group in the molecule of non-thiol drugs may be responsible for inducing pemphigus. Table 2: Common cutaneous adverse reactions and the antihypertensives that have been implicate Rare autosomal dominant genetic disorder that leads to abnormal blood vessel formation in the skin, mucous membranes, and often in organs such as the lungs, liver, and brain. It may lead to nosebleeds, acute and chronic digestive tract bleeding, and various problems due to the involvement of other organs. Wikipedia