Interim Statement Regarding Potential Fetal Harm from Exposure to Dolutegravir - Implications for HIV Post-exposure Prophylaxis (PEP). Please see attached PDF. [PDF - 104 KB]. PEP is the use of antiretroviral drugs after a single high-risk event to stop HIV seroconversion. PEP must be started as soon as possible to be effective—and always. . PEP is the use of antiretroviral medication to prevent HIV infection in an HIV-negative person who has had a specific high-risk exposure to HIV
For percutaneous (needlestick), ocular, or mucous-membrane exposure to blood known to contain HBsAg and for human bites from HBsAg carriers that penetrate the skin, a single dose of HBIG (0.06 ml/kg or 5.0 ml for adults) should be given as soon as possible after exposure and within 24 hours if possible In the Centers for Disease Control and Prevention (CDC) Needlestick Surveillance Group study, use of zidovudine (as post-exposure prophylaxis [PEP]) by healthcare workers reduced the risk of HIV acquisition by 81% overall for percutaneous exposures [Cardo, et al. 1997]. With the use of potent antiretroviral (ARV) medications that have increased. Postexposure Prophylaxis to Prevent Hepatitis B Virus Infection. MMWR 2018;67 (No. RR-1):1-31. Postexposure Prophylaxis section provides recommendations for management of persons who are exposed to HBV through a distinct, identifiable exposure to blood or body fluids that contain blood, in occupational and nonoccupational settings Other Nonoccupational Exposure to HIV— United States, 2016 from the Centers for Disease Control and Prevention, U.S. Department of Health and Human Services . Update: Interim Statement Regarding Potential Fetal Harm from Exposure to Dolutegravir - Implications for HIV Post-exposure Prophylaxis (PEP). Please see attached file
Post-exposure prophylaxis, Hepatitis B CDC Viral Hepatitis - Hepatitis B Information topic page for Postexposure Prophylaxis. Post-exposure prophylaxis (HIV and other bloodborne pathogens) The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website CDC now recommends the 4-6 month post-exposure anti-HCV test out of an abundance of caution because of the potential for periods of intermittent aviremia during acute infection described in several earlier publications, primarily when older HCV RNA testing methodologies were used Updated: June 18, 2021. These NCCC post-exposure prophylaxis (PEP) recommendations will help you with urgent decision-making for occupational exposures to HIV and hepatitis B and C. Consultation can be obtained from Occupational Health or Employee Health Services, local experts, or the NCCC's PEPline Centers for Disease Control and Prevention Needlestick Surveillance Group. N Engl J Med. 1997 Nov 20. 337(21):1485-90. . CDC. Public Health Service guidelines for the management of health-care worker exposures to HIV and recommendations for postexposure prophylaxis. Centers for Disease Control and Prevention
Call the PEP (post-exposure prophylaxis) hotline at 1-888-448-4911 immediately for guidance on treating exposures. Promptly report the needlestick exposure injury and seek care from a licensed healthcare provider at an occupational health clinic, urgent care, emergency department, or your healthcare provider for appropriate treatment In Part 1 of this two-part series, we'll review the cur- rent CDC guidelines, the pathogenicity of the viruses, the pre and post exposure management of exposed health care workers, and preexposure prophylaxis and post-exposure management for hepatitis B and C. Part 2, in a subsequent issue, will review definitions of HIV transmission risk. From the CDC: Updated U.S. Public Health Service guidelines for the management of occupational exposures to HBV, HCV, and HIV and recommendations for post-exposure prophylaxis. MMWR. 2001:50 (No. RR-11) (updated as issued). From the CDC: CDC Guidance for Evaluating Health-Care Personnel for Hepatitis B Viru Post-exposure prophylaxis (PEP) means taking HIV medicines within 72 hours after a possible exposure to HIV to prevent HIV infection. PEP should be used only in emergency situations. It is not meant for regular use by people who may be exposed to HIV frequently. PEP must be started within 72 hours (3 days) after a possible exposure to HIV when a needle stick injury has been made with a large gauge needle. In general, the risk of transmission is much greater for HBV than for both HCV and HIV. Risk of transmission for each of the 3 pathogens is summarized here. HBV The risk of transmission of HBV following a needle stick exposure from an infected source ranges from 6 to 30%(2.
Though there is an immunization for HBV, HIV post-exposure prophylaxis is effective and HCV treatments can be successful, there are more than 20 other bloodborne pathogens to which healthcare workers may be exposed. For this reason, we must continue to focus on preventing injuries and exposures Pathogens Standard and CDC's Universal Precautions12 (Post-exposure prophylaxis (PEP) is essential to reduce the risk of transmission and should be started within two hours of exposure—see page 10).13 • The transmission rate of occupationally acquired HIV after an exposure is 0.3% (1 in 300)
Nonsexual, Nonoccupational Exposures. Nonsexual, nonoccupational exposures that are associated with a risk for transmission of HIV include procedures that involve percutaneous penetration (e.g., needlestick injection, piercing, cutting with a sharp object); contact with mucous membranes; or contact with skin (especially when the involved skin is chapped, abraded, or affected by dermatitis or. However, today the major concern after a needlestick injury is not HIV but hepatitis B or hepatitis C. Guidelines have been established to help healthcare institutions manage needlestick injuries and when to initiate post-exposure HIV prophylaxis. The Centers for Disease Control and Prevention (CDC) has developed a model which helps healthcare. Determine the exposure type and HIV infection status/viral load of the source; Post Exposure Prophylaxis should be started within 1-2 hours if you are at high risk, but may be efficacious if started any time within 72 hours. Initial Treatment of Exposed Healthcare Professional. Hepatitis B Viru PEP: Post-Exposure Prophylaxis Timely answers for urgent exposure management Get rapid, expert guidance in managing healthcare worker exposures to HIV and hepatitis B and C, including recommendations on when and how to initiate PEP through our online Quick Guide for urgent occupational PEP decision-making, or from experienced clinicians on our. Other BBF exposure protocols will be instituted, as indicated. EOHW staff will review the type of exposure, employee status, patient source requesting HIV ab testing as necessary, make a decision on risk, and counsel the exposed employee offering the appropriate post exposure prophylaxis (PEP) based on CDC guidelines*. Source patient will b
It is necessary to determine the status of the exposure and the HIV status of the exposure source. before starting post exposure prophylaxis (PEP). Step 1: Immediate measures. For skin — if the skin is broken after a needle-stick or sharp instrument: · Immediately wash the wound and surrounding skin with water and soap, and rinse. Do not scrub Management of needlestick injuries: a house officer who has a needlestick. to Dolutegravir-- Implications for HIV Post-exposure Prophylaxis (PEP. CDC.GOV of ritonavir-boosted darunavir for. This educational packet is a curated compilation of resources on post-exposure prophylaxis (PEP). to HIV at work, for example, from a needlestick injury. A health care worker who has a The Centers for Disease Control and Prevention (CDC) provides guidelines o
Post-exposure prophylaxis should be initiated after evaluation by the appropriate occupational health department. General principles include: HIVRisk after needlestick: Ranges from 0.3 - 0.9%. Needle Stick Injury Protocol Blood Test. Blood exposure profile for healthcare workers. $362.00 $249.00 ORDER NOW. Sample Report. Test Code: 322755, 140659, 083935, 006530, 006718, 006510. Specimen Type: Blood. Description: Needle Stick Injury Protocol Blood Test. This package screens for several bloodborne diseases which pose a risk to workers. We recently blogged about a healthcare worker who was on the receiving end of a needlestick injury. The source patient agreed to be tested for HIV and hepatitis B and C. While the initial HIV test was positive, repeat testing was negative. Great news. The healthcare worker had been placed on post-exposure prophylaxis and it was discontinued.
Risk: The risk of seroconversion following a needlestick with blood from an HIV-infected patient depends on several factors. However, on average, if no post-exposure prophylaxis is given, the risk is about 0.33% after a needlestick injury. Infection from mucosal exposure has been reported, but rates are very low, around 0.09%3 In the Centers for Disease Control and Prevention (CDC) Needlestick Surveillance Group study, use of zidovudine (as post-exposure prophylaxis [PEP]) by healthcare workers reduced the risk of HIV acquisition by 81% overall for percutaneous exposures [Cardo, et al. 1997] Postexposure prophylaxis (PEP) is effective in preventing illness after potential or documented exposure to a variety of microbial pathogens and in reducing the risk of secondary spread of infection
Virus and Recommendations for Post-Exposure Prophylaxis (PEP). The recommendations are published in Control . Following national guidelines issued by the United States Public Health Service Centers for Disease Control and Prevention (CDC), exposure is contact with blood or body fluids, needle stick/HIV exposure protocol. Alberta Guidelines for Post-Exposure Management and Prophylaxis: HIV, Hepatitis B, Hepatitis C and Sexually Transmitted Infections Ministry of Health, Government of Albert Rates of disease transmission are significantly reduced with timely and appropriate post-exposure antiviral prophylaxis. Additional Reading. Overview: Risks and Prevention of Sharps Injuries in Healthcare Personnel. Centers for Disease Control and Prevention; Atlanta: 2004. Davenport A, Myers F. How to protect yourself after body fluid exposure PEP, or post-exposure prophylaxis, is a short course of HIV medicines taken very soon after a possible exposure to HIV to prevent the virus from taking hold in your body. You must start it within 72 hours (3 days) after a possible exposure to HIV, or it won't work. Every hour counts! PEP should be used only in emergency situations experienced in the application of CDC post-exposure prophylaxis, and available for medical evaluation and follow-up care, including baseline and follow-up labs. (2) If PEPline does not recommend PEP after a percutaneous injury from an unknown source. If an employee has incurred a percutaneous exposure to blood or other potentially infectiou
• A blood or body fluid exposure that occurs as a consequence of a work-related activity • There are two types of blood and body fluid exposure: • Percutaneous exposure (penetrates the skin) e.g. needle stick injury (NSI) or cut with a sharp object such as a scalpel blade • Non-percutaneous or Mucocutaneous exposure (contact of mucous. Prophylaxis of Needlestick Injury or Mucosal Contact to HBV, HCV and HIV Background Occupational exposure to blood-borne pathogens is a well-recognised hazard to health care workers (HCW). Adherence to standard infection control practices is the best way to prevent blood-borne infections in the health care setting appropriate postexposure management is an important element of workplace safety. In 1990, the Centers for Disease Control and Prevention (CDC) issued a statement that management of occupational exposure to HIV should consider use of zidovudine for postexposure prophylaxis (PEP). The first iteration of the U.S. Publi The first thing to consider is whether or not this is a clinically relevant exposure, and therefore if the health care worker even needs prophylaxis. If the exposure is to intact skin, to any of the following, the answer is no, and the patient can be discharged. Easy! If the exposure is from any of these fluids: And comes in contact with mucous. Links with this icon indicate that you are leaving the CDC website.. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. Linking to a non-federal Website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website
Guidelines on HIV post-exposure prophylaxis have recently been updated by the UK Health Departments. 24 There are practical difficulties and substantial inconvenience to obtaining advice following. Human immunodeficiency virus. Contracting HIV after needlestick injury is rare. From 1981 to 2006, the CDC documented only 57 cases of HIV/AIDS in healthcare workers following occupational exposure and identified an additional possible 140 cases post-exposure.5,6 Of the 57 documented cases, 48 sustained a percutaneous injury Dolezal C, Frasca T, Giguere R, et al. Awareness of Post-Exposure Prophylaxis (PEP) and Pre-Exposure Prophylaxis (PrEP) Is Low but Interest Is High Among Men Engaging in Condomless Anal Sex With Men in Boston, Pittsburgh, and San Juan. AIDS Educ Prev. 2015;27:289-97
While the risk of transmission from an occupational exposure to a source patient with an undetectable serum viral load is thought to be very low, post exposure prophylaxis (PEP) should still be considered.4 In 1997, the CDC Needlestick Surveillance Group published findings from a study looking at the risk of HIV transmission among health care. Needle stick Injury 1. Needle StickNeedle Stick && Post Exposure ProphylaxisPost Exposure Prophylaxis 2. HCW/HCP Exposure - NSIHCW/HCP Exposure - NSI An exposure that might place HCP at risk for HBV, HCV, or HIV infection • A per-cutaneous injury (e.G., A needle-stick or cut with a sharp object) or • Contact of mucous membrane or non-intact skin (e.g., exposed skin that is chapped. More information on post-exposure prophylaxis can be found on the CDC Web site. Counseling may also be provided to an exposed employee. Counseling includes information about the risks of developing infections as a result of the exposure, signs and symptoms to watch for, precautions to take, and recommendations for additional testing in the future In the case of HIV exposure, post-exposure prophylaxis (PEP) is a course of antiretroviral drugs which reduces the risk of seroconversion after events with high risk of exposure to HIV (e.g., unprotected anal or vaginal sex, needlestick injuries, or sharing needles ) Definition of Occupational Exposure An occupational exposure that may place an employee at risk of HIV infection is defined as a percutaneous injury (e.g., a needlestick or cut with a sharp object), contact of mucous membranes, or contact of skin (especially when the exposed skin is chapped, abraded, or afflicted with dermatitis or when the contact is prolonged or involves an extensive area.
Post-exposure prophylaxis, or PEP, is a way to help prevent the transmission of HIV in an HIV-negative person who may have been recently exposed to the virus. It involves taking HIV medications as soon as possible after a potential exposure to HIV. Anyone who thinks they may have been exposed to HIV should contact their doctor, a hospital. One such recommendation, which has been modified relatively recently, is the protocol for post-exposure prophylaxis (PEP) of percutaneous injury with known HIV-contaminated blood. 1 This change has been supported by the Canadian Medical Association and other agencies concerned with infection control and aseptic procedures in health care. Federal law requires covered employers to ensure that all medical evaluations and procedures, vaccines, and post-exposure prophylaxis are made available to the employee within a reasonable time.
Exposure to human immunodeficiency virus (HIV) can occur in a number of situations unique to, or more common among, children and adolescents. Guidelines for postexposure prophylaxis (PEP) for occupational and nonoccupational (eg, sexual, needle-sharing) exposures to HIV have been published by the US Public Health Service, but they do not directly address nonoccupational HIV exposures unique to. PEP (Post-Exposure Prophylaxis) PEP is immediate treatment that may prevent infection after being exposed to HIV. This may include: A needle-stick injury or an exposure to blood, semen or vaginal fluid that gets into the bloodstream via a cut or open wound-sore or comes into contact with a mucous membrane (eyes, nose, mouth) Post-exposure prophylaxis (PEP) is a four-week course of medication that may block HIV infection after exposure to the virus. You can read an overview of PEP here.PEP should not be confused with pre-exposure prophylaxis (PrEP), which involves taking medicine on an ongoing basis, before possible exposure to HIV.. The most accurate way to test the efficacy of PEP would be to conduct randomised.
4. POST-EXPOSURE PROPHYLAXIS FOR HIV 4.1 New recommendations on post-exposure prophylaxis for HIV 4.1.1 Background ARV drugs have been prescribed for post-exposure prophylaxis following occupational exposure to HIV for health workers since the early 1990s. During the past two decades, the provision of HIV post-exposure prophylaxis has been extende Needlestick injuries (NSIs) can transmit bloodborne pathogens, including hepatitis The Centers for Disease Control and Prevention (CDC) states that post-exposure prophylaxis (PEP) for exposure to HIV should begin as soon as possible and no later than 72 hours after the incident. 11, 1 After a needlestick exposure to an infected patient, a HCW's risk of infection depends on the pathogen involved, the immune status of the worker, the severity of the injury, and the availability and use of appropriate post-exposure prophylaxis. CDC data suggests that the rate of transmis-sion to HCWs after a needlestick exposure for HBV, HCV an
To the Editor: Lassa fever is an acute, viral, hemorrhagic illness endemic to West Africa. Intravenous ribavirin drastically reduces deaths from Lassa fever ().During outbreaks, oral ribavirin is often considered for postexposure prophylaxis (PEP), but no systematically collected data exist for this indication of drug use (1-5).We therefore conducted a retrospective follow-up study to. tuberculosis exposure and vector-borne illness, one of the most serious concerns reported to the Exposure Control Officer is that of needlestick and sharps injuries. These injuries have occurred in several ways ranging from injuries while using overfilled sharps containers, to injuries caused by unintentional patient movement Federal and best-practice recommendations for post-exposure prophylaxis (PEP) decisions. The following guidelines and guidances from U.S.P.H.S, the CDC, and current literature provide information on identifying, managing, and following up on potential exposures to HIV and hepatitis B and C Post Exposure Prophylaxis Issues. Animal Studies of PEP Efficacy • Data have been difficult to interpret and extrapolate to humans, but provide encouraging evidence of the effectiveness of PEP • Reduced PEP effectiveness if: - Large dose of inocula - Delay in time to PE
I. Post-Exposure Prophylaxis (PEP): a defined regimen, as formulated by the CDC, to aid in the prevention of the development of infection with HIV and prescribed by an evaluating institution or physician. J. Post-Exposure Management Team: a team of individuals identified usually by the SOM/UP&S Safety Officer o oPEP stands for occupational post-exposure prophylaxis. It's when a health care worker takes PEP because of a possible exposure to HIV while working, such as from a needlestick injury Needle Stick Injury Protocol, Prevention and Management. Needle Stick Injury and Accidental Exposure to Blood. Needlestick Injury : the accidental puncture of the skin by a needle during a medical intervention Accidental exposure to blood: the unintended contact with blood and or with body fluids mixed with blood during a medical intervention.. Risk
Fätkenheuer G, Jessen H, Stoehr A, et al. PEPDar: A randomized prospective noninferiority study of ritonavir-boosted darunavir for HIV post-exposure prophylaxis. HIV Med . 2016 Jun. 17 (6):453-9. Start post-exposure prophylaxis as soon as possible. Reevaluate the exposed individual within 72 hours, particularly focusing on new information regarding the source and the exposure. If the source is determined to be HIV-negative, post-exposure prophylaxis can be discontinued. If the source is determined to be HIV-positive, continue treatment. A randomized noninferiority trial of standard versus enhanced risk reduction and adherence counseling for individuals receiving post-exposure prophylaxis following sexual exposures to HIV. Clin. In 2011, the CDC reconvened the interagency PHS working group to plan and prepare an update to the 2005 Updated U.S. Public Health Service Guidelines for the Management of Occupational Exposures to HIV and Recommendations for Post-exposure Prophylaxis.6 The PHS working group was comprised of members from the CDC, the FDA, the Health Resource
Postexposure prophylaxis (PEP) is recommended for health-care personnel who have occupational exposure to blood or other body fluids that may contain human immunodeficiency virus (HIV). [1, 2] The HIV status of the exposure source patient should be determined, if possible, to guide the need for HIV PEP.PEP medication regimens should be started as soon as possible after occupational exposure to. Needle stick injury. Needle stick injury is defined as any percutaneous injury, penetration of skin resulting from a needle or other sharp object, which has been in contact with blood, tissue, or other body fluids prior to the exposure 1).The United States Centers for Disease Control and Prevention (CDC) estimates that about 600,000-1,000,000 needle stick injuries occur annually 2) from a single needle stick or a cut exposure to HBV-infected blood ranges from 6%-30% and did not have post- vaccination antibody testing, CDC recommends antibody testing body substance involved and the route and severity of the exposure. Post-exposure prophylaxis is based on whether the exposed person has been previously vaccinated an
Needlestick injuries continue to be a common source of work related injury among health care professionals. Since the Needle-Stick Safety and Prevent act of 2000, non-surgical needle sticks have decreased by 31.6% (2001-2006). Over this same time period, incidents within the surgical setting have increased 6.5% Of the 58 confirmed cases, all but four occurred between the years 1985 and 1995, just prior to the advent of antiretroviral therapy (ART) and the release of the first U.S. guidelines for the use of post-exposure prophylaxis (PEP) in cases of accidental HIV exposure Guidelines for prophylaxis after occupational exposure are available from the CDC and the Department of Health and Human Services (DHHS). 13,55 They are also available from the New York State. Postexposure prophylaxis (PEP) is medical care given to prevent HIV, hepatitis B, and other diseases. PEP may include first aid, testing, and medicines. Exposure can occur when you have contact with certain body fluids from another person. These fluids include blood, semen, and vaginal fluid
The CDC has a post exposure prophylaxis hotline at 1-888-448-4911 Clinical Features Frequently from needlestick injuries or other occupational exposures to bodily fluid Which patient exposure by the nurse is most likely to require postexposure prophylaxis when the patient's human immunodeficiency virus (HIV) status is unknown? a. Needle stick injury with a suture needle during a surgery b. Splash into the eyes while emptying a bedpan containing stool c. Needle stick with a needle and syringe used for a.
HIV Post-Exposure Prophylaxis (PEP) Guidelines. March 2020. PEP Guidelines: For information on how to obtain medication for prevention of HIV infection following a high risk occupational or non-occupational exposure, please call the St Paul's Hospital Ambulatory Pharmacy 1-888-511-6222 . Such strategies focus on consideration of modes and risk of transmission, baseline and follow-up testing, and prophylaxis CDC: Better needlestick reporting required Post-exposure protocol expected to improve rates. A recent study of percutaneous injuries from phlebotomy devices fell in line with previous studies showing that only about half the injuries were reported to hospital surveillance systems Post-Exposure Prophylaxis (PEP) The use of therapeutic agents to prevent infection following exposure to a pathogen Types of exposures: percutaneous (needlestick), splash, bite, sexual For health-care workers, PEP commonly considered for exposures to HIV and Hepatitis Postexposure Prophylaxis. Postexposure prophylaxis (PEP) has been used in situations where uninfected persons have been identified as having a recent high-risk exposure to an HIV-1-infected person or to blood or blood products that have a high probability of being infected with HIV-1. PEP has been most commonly used after occupational exposures
. Although the risk of contracting a blood-borne pathogen is low, the psychological trauma that follows the injury can be disabling. However, where the risk is significant, the immediate administration of post-exposure prophylaxis may reduce the chance of seroconversion to some pathogens (reviewed May 2016) Hepatitis B post-exposure prophylaxis Hepatitis B vaccine is highly effective in preventing acute infection after exposure if given within 7 days and preferably within 48 hours. Hepatitis B immunoglobulin (HBIG) is only indicated where the source is known HBsAg positive, or where the recipient is a known non-responder to HBV. BASELINE TESTS TO CONSIDER FOR PERSONS BEING SEEN FOR NONOCCUPATIONAL POST- EXPOSURE PROPHYLAXIS (nPEP): Gonorrhea & chlamydia (GC/CT) 1 - swabs of all sites of sexual contact including oropharyngeal, rectal, and genital: urine testing may be considered in place of genital testing Rapid HIV Ag/Ab testing 2,3 Urine pregnancy tes Post-Exposure Prophylaxis (PEP) The use of therapeutic agents to prevent infection following exposure to a pathogen High risk exposures are grouped into: -Occupational • Needle stick or other injury that pierces the skin or draws blood • Contact with another person's blood or other bodily fluid CDC Recommends Post HIV Exposure Prophylaxis For All The most direct evidence supporting the efficacy of postexposure prophylaxis is a case-control study of needlestick injuries to health-care workers. In this study, the prompt initiation of zidovudine was associated with an 81% decrease in the risk for acquiring HIV (21). Although.
If you have unanswered questions after a BBP exposure/needlestick, contact: Office of Academic Affairs: 206-543-5560 (8am-5pm PST) Spokane students - call UWSOM Spokane Office: 509-313-7900 (7:30am-4:30pm PST) If after hours: 206-906-8996. Identify yourself as a UWSOM student (or provider) with a blood-borne exposure, and request to speak. In cases of possible exposure to HIV, the use of PEP (post-exposure prophylaxis) has been found to greatly reduce the risk of HIV infection. For PEP to work, it must be initiated within 72 hours of exposure and taken every day for 28 consecutive days, exactly as directed . It is important that dentist and all workers are vaccinated. Pre-exposure prophylaxis consists of administration of a 3 dose series of hepatitis B vaccine given over a-month period. › Dose # 1 is time zero › Dose # 2 given one month after dose #1 › Dose # 3 is given months after dose #1 Adolescents aged 11-15 years have the option. The HIV postexposure prophylaxis registry: Final report, 17 October 1996 through 31 March 1999. The Centers for Disease Control and Prevention, Glaxo Wellcome Inc, Merck and Co, Inc. March 1999. Parkin JM, Murphy M, Anderson J, et al. Tolerability and side-effects of post-exposure prophylaxis for HIV infection. Lancet 2000; 355:722
Needle-stick injuries. Injuries from needles used in medical procedures are sometimes called needle-stick or sharps injuries. If there's a high risk of infection with HIV, your healthcare professional may consider treatment called post-exposure prophylaxis (PEP). Getting support . AFTER EXPOSURE. The Centers for Disease Control and Prevention (CDC) recommends a combination of two or three medications to prevent developing HIV after exposure; the best regimen should be determined by a healthcare.